The Bryan brothers were beaten in the semi finals of the ATP Western & Southern Open on Saturday.
The top ranked twins lost to fourth seeds Robert Lindstedt and Horia Tecau 7-5, 6-7(5), 10-2. Lindstedt and Tecau hit 17 aces in the match winning it in one hour and 34 minutes.
They will meet sixth seeds Mahesh Bhupathi and Rohan Bopanna in the final.
The Indian duo beat Ivan Dodig and Marcelo Melo 6-4, 6-3. The Indians are hoping to win their second title of the year. Bhupathi had won this event last year with former partner Leander Paes.