Serbia's Janko Tipsarevic became the ninth player at this year's US Open to battle back from a two sets to love deficit.
That equals an Open era record for most such comeback during any entire Grand Slam event.
Tipsarevic was one of three players to achieve the same on Wednesday along with Luxembourg’s Gilles Muller and Latvian Ernests Gulbis.
Tipsarevic beat France’s Guillaume Rufin 4-6, 3-6, 6-2, 6-3, 6-2 in three hours and 37 minutes. It was the fifth time he has come back from two sets down in his career.
Muller upset No. 28 seed Mikhail Youzhny of Russia 2-6, 3-6, 7-5, 7-6(6), 7-6(6) in four hours and 23 minutes and meets former world no. 1 Lleyton Hewitt next.
Gulbis beat 34-year-old German Tommy Haas 3-6, 4-6, 6-4, 7-5, 6-3 in his comeback ending the hopes of the 21st seeded German
Gulbis will now meet current NCAA men's singles champion Steve Johnson, who battled past fellow American Rajeev Ram 6-3, 7-6(5), 6-3 for his first ever win in a grand slam