American Varvara Lepchenko upset No.7 seed Johanna Larsson 6-2, 6-4 at the WTA event in Memphis on Tuesday.
"I played great. I was really aggressive and I used all my weapons," Lepchenko told the media. "With every match, I'm playing better and better."
Fourth-seeded Marina Erakovic, Vera Dushevina and Michaella Krajicek also reached the last eight.
Former Wimbledon quarter finalist Krajicek scored a 76(2) 63 win over Olga Govortsova.
In first round action no..2 seed Ksenia Pervak and No.5 seed Pauline Parmentier won their matches.