Anastasia Pavlyuchenkova played her first WTA main draw as a wildcard at 2006 Moscowmade Top 100 debut on July 7 (rose from No.137 to No.92) and Top 50 debut on November 3 (rose from No.56 to No.45). In 2010 she won two WTA titles at Monterrey (d. Hantuchova in final) and Istanbul (d. Vesnina in final), in 2011 she defended her title in Monterrey and reached eached last eight at 2011 Roland Garros (l. eventual champion Schiavone), 2011 US Open (l. eventual champion S.Williams), comleting the season at No.16.
Runner-up in Washington in 2012, she won two titles in 2013 in Monterrey (d. Kerber in final) and Oeiras (d. Suárez Navarro in final) finishing at No.26. In 2014 and 2015 she was able to finish the season in top 30 and added three titles to her tally, winning at 2014 Paris [Indoors] (d. Sharapova in F), 2014 Moscow (d. Begu in F), 2015 Linz (d. Friedsam in F).
She posted her fourth Top 30 season in a row in 2016. In addition to reaching last eight at 2016 Wimbledon, reached a further six quarterfinals in 2016: in Brisbane (l. Kerber), St.Petersburg (l. Bencic), Acapulco (l. Wickmayer), Montréal (l. Keys), Linz (l. Cibulkova) and Moscow (l. Gavrilova).
Pavlyuchenkova opened 2017 completing a set of career Grand Slam quarterfinals by reaching this stage at 2017 Australian Open (l. eventual R‐Up V.Williams). A 10‐match winning streak helped her to win back‐to‐back titles in Monterrey (d. Kerber in F) and Rabat (d. Schiavone in F). In the Asian Swing she lifted her 11th title in Hong Kong (d. Gavrilova). Then she contested Zhuhai as World No.14 – her best ranking since reaching career‐high No.13 in summer 2011 – but failed to pass to the semifinals.