Alexandr Dolgopolov was born in Kiev on November 7, 1988. Dolhopolov was born into a sporting family: his father Oleksandr Dolhopolov was also a tennis player, while his mother was a gymnast.
He started playing tennis at the age of 3, coached by his father who was also the coach of Andrij Medvedjev, one of the most famous Ukrainian tennis players. At a young age Dolhopolov, on tour with his parents in various tournaments, saw Medvedjev, Agassi, and Becker play among others. Jim Courier remembers dribbling with Dolhopolov when he was a kid.
He made his ATP Tour debut in 2006 at the BCR Open Romania as a qualifier; he was defeated in the first round by Christophe Rochus. He was also part of Ukraine's Davis Cup team in the meetings with Great Britain, and was defeated by Andy Murray.
At the age of 33, due to the Russian military invasion of Ukraine which began in February 2022, he fled to Turkey with his family. In March, he returned to his country and joined the army to fight the invaders, serving in Kiev.