Anne Keothavong was born in Hackney on 16 September 1983.
Her parents are Somsak and Vathana, both immigrants from Laos, who met while attending the Laotian communities of London and Portsmouth. She has a sister named Lena and two brothers, James and Mark. Born and raised in London, she inherited her father's passion for tennis and started playing with her brother James. She was educated at Kingsland Secondary School in London.
In 2007, she won a $50,000 ITF tournament for the first time in Vancouver. In May 2008 she won another $50,000 tournament in Lebanon and the following week she entered the top 100 of the WTA rankings for the first time.
Throughout his career, his main rival among compatriots is Elena Baltacha, against whom he often played from a very young age, who in turn would make the top 50. Keothavong represents Great Britain at the 2012 London Olympics in singles and in double teamed with Baltacha, without achieving medals.
She achieved her best result in the WTA tournaments at the end of her career by reaching the final in doubles paired with Valerija Savinych at the 2013 Brasil Tennis Cup, in which they were defeated in straight sets by Anabel Medina Garrigues / Jaroslava Shedova. She never wins any WTA tournament, but she reaches the semifinals 7 times, while she wins a total of 20 ITF singles and 8 doubles titles in her career.
After leaving competition, she started working for BT Sport's tennis team. At the end of 2016 she became the captain of the British Fed Cup team. She also works in television as a commentator for tennis tournaments.
On February 28, 2015, she married Andrew Bretherton, with whom she fathered daughter Ava in 2015.